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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela; INIA Las Brujas. |
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Fecha : |
18/02/2019 |
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Actualizado : |
24/10/2022 |
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Tipo de producción científica : |
Serie FPTA |
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Autor : |
PÉREZ, R.; MARANDINO, A.; TOMÁS, G.; PANZERA, Y.; HERNÁNDEZ, M.; HERNÁNDEZ, D.; MILANO, A.; TECHERA, C.; GRECCO, S. |
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Afiliación : |
RUBEN PÉREZ, Universidad de la República (UdelaR)/ Facultad de Ciencias; ANA MARANDINO, Universidad de la República (UdelaR)/ Facultad de Ciencias; GONZALO TOMÁS, Universidad de la República (UdelaR)/ Facultad de Ciencias; YANINA PANZERA, Universidad de la República (UdelaR)/ Facultad de Ciencias; MARTÍN HERNÁNDEZ, Universidad de la República (UdelaR)/ Facultad de Ciencias; DIEGO HERNÁNDEZ, Universidad de la República (UdelaR)/ Facultad de Ciencias; ANDRÉS MILANO, Universidad de la República (UdelaR)/ Facultad de Ciencias; CLAUDIA TECHERA, Universidad de la República (UdelaR)/ Facultad de Ciencias; SOFÍA GRECCO, Universidad de la República (UdelaR)/ Facultad de Ciencias. |
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Título : |
Incorporación de técnicas moleculares y bioinformáticas en avicultura para la investigación epidemiológica y el diseño de estrategias de control y prevención de
Gumboro y Bronquitis Infecciosa. |
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Fecha de publicación : |
2019 |
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Fuente / Imprenta : |
Montevideo (UY): INIA, 2019. |
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Páginas : |
35 p. |
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Serie : |
(Serie FPTA-INIA; 74). |
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ISBN : |
978-9974-38-414-9 |
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ISSN : |
1688-924X |
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Idioma : |
Español |
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Notas : |
Proyecto FPTA-319: Incorporación de técnicas moleculares y bioinformáticas en avicultura para la investigación epidemiológica y el diseño de estrategias de control y prevención de Gumboro y Bronquitis Infecciosa. Periodo de ejecución: Marzo 2014 - Agosto 2017. Institución Ejecutora: Universidad de la República, Facultad de Ciencias. Responsable técnico del proyecto: Ruben Gustavo Pérez Crossa. |
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Contenido : |
Los virus de Gumboro y Bronquitis infecciosa generan graves pérdidas en la industria avícola mundial. Ambos virus están presentes en Uruguay, por lo que es necesario conocer su estado de situación local y diseñar planes de control y prevención ajustados a la realidad nacional. Durante esta investigación se obtuvo información epidemiológica para el control de estos virus mediante el desarrollo y aplicación de herramientas de análisis (genéticas, serológicas y bioinformáticas). |
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Palabras claves : |
VIRUS AVIARES. |
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Thesagro : |
AVICULTURA; ENFERMEDADES DE LOS ANIMALES; EPIDEMIOLOGIA (URUGUAY); SANIDAD ANIMAL; VIROSIS. |
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Asunto categoría : |
L73 Enfermedades de los animales |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/12459/1/inia-fpta-74-proyecto-319-2019.pdf
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Marc : |
LEADER 01917nam a2200337 a 4500
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005 2022-10-24
008 2019 bl uuuu u00u1 u #d
020 $a978-9974-38-414-9
022 $a1688-924X
100 1 $aPÉREZ, R.
245 $aIncorporación de técnicas moleculares y bioinformáticas en avicultura para la investigación epidemiológica y el diseño de estrategias de control y prevención de Gumboro y Bronquitis Infecciosa.$h[electronic resource]
260 $aMontevideo (UY): INIA$c2019
300 $a35 p.
490 $a(Serie FPTA-INIA; 74).
500 $aProyecto FPTA-319: Incorporación de técnicas moleculares y bioinformáticas en avicultura para la investigación epidemiológica y el diseño de estrategias de control y prevención de Gumboro y Bronquitis Infecciosa. Periodo de ejecución: Marzo 2014 - Agosto 2017. Institución Ejecutora: Universidad de la República, Facultad de Ciencias. Responsable técnico del proyecto: Ruben Gustavo Pérez Crossa.
520 $aLos virus de Gumboro y Bronquitis infecciosa generan graves pérdidas en la industria avícola mundial. Ambos virus están presentes en Uruguay, por lo que es necesario conocer su estado de situación local y diseñar planes de control y prevención ajustados a la realidad nacional. Durante esta investigación se obtuvo información epidemiológica para el control de estos virus mediante el desarrollo y aplicación de herramientas de análisis (genéticas, serológicas y bioinformáticas).
650 $aAVICULTURA
650 $aENFERMEDADES DE LOS ANIMALES
650 $aEPIDEMIOLOGIA (URUGUAY)
650 $aSANIDAD ANIMAL
650 $aVIROSIS
653 $aVIRUS AVIARES
700 1 $aMARANDINO, A.
700 1 $aTOMÁS, G.
700 1 $aPANZERA, Y.
700 1 $aHERNÁNDEZ, M.
700 1 $aHERNÁNDEZ, D.
700 1 $aMILANO, A.
700 1 $aTECHERA, C.
700 1 $aGRECCO, S.
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Registro original : |
INIA Las Brujas (LB) |
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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha actual : |
07/06/2019 |
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Actualizado : |
05/09/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
GIANNITTI, F.; CAFFARENA, D.; PESAVENTO, P.; UZAL, F.A.; MAYA, L.; FRAGA, M.; COLINA, R.; CASTELLS, M. |
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Afiliación : |
FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; RUBEN DARÍO CAFFARENA LEDESMA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; PATRICIO PESAVENTO, Pathology, Microbiology and Immunology Department, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.; FRANCISCO ALEJANDRO UZAL, Pathology, Microbiology and Immunology Department, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.; LETICIA MAYA, Laboratorio de Virología Molecular, Centro Universitario Regional (CENUR) Litoral Norte, Universidad de la República, Salto, Uruguay.; MARTIN FRAGA COTELO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; RODNEY COLINA, Laboratorio de Virología Molecular, Centro Universitario Regional (CENUR) Litoral Norte, Universidad de la República, Salto, Uruguay.; MATÍAS CASTELLS BAUER, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay.//Laboratorio de Virología Molecular, Centro Universitario Regional (CENUR) Litoral Norte, Universidad de la República, Salto, Uruguay. |
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Título : |
The first case of bovine astrovirus-associated encephalitis in the southern hemisphere (Uruguay), uncovers evidence of viral introduction to the Americas from Europe. |
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Fecha de publicación : |
2019 |
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Fuente / Imprenta : |
Frontiers in Microbiology, volumen 10, Article 1240, 04 June 2019. [OPEN ACCESS].Doi: https://doi.org/10.3389/fmicb.2019.01240 |
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DOI : |
10.3389/fmicb.2019.01240 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received: 22 March 2019//Accepted: 17 May 2019//Published: 04 June 2019. This work was funded by Grants PL-015 N-15156 from INIA and 158 from the ?Programa de Iniciación a la Investigación 2017? from ?Comisión Sectorial de Investigación Científica? (CSIC). MC and RDC acknowledge support from the ?Agencia Nacional de Investigación e Innovación? (ANII) and INIA, respectively, through Ph.D. scholarships. FG acknowledges support from ANII through mobility grant MOV_CA_2018_1_150021. |
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Contenido : |
Abstract: Astrovirus species members of the Mamastrovirus genus (family Astroviridae) have been increasingly recognized as neuroinvasive pathogens in various mammals, including humans, mink, cattle, sheep, and pigs. While cases of astrovirus-associated encephalitis have been reported in North America, Europe, and Asia, their presence has never been documented in the Southern hemisphere. This paper describes a case of astrovirus-associated encephalitis in cattle in Uruguay that broadens the geographic distribution and genetic diversity of neuroinvasive astroviruses and provides phylogeographic evidence of viral introduction to the Americas from Europe. A 22-month-old Holstein steer from a farm in Colonia Department, Uruguay developed progressive neurological signs over a 3-days period before dying. Histopathological examination of the brain and proximal cervical spinal cord revealed disseminated, moderate to severe lymphocytic, histiocytic, and plasmacytic poliomeningoencephalomyelitis with neuronal necrosis. A Mamastrovirus strain in the CH13/NeuroS1 clade, that we called bovine astrovirus (BoAstV)-Neuro-Uy, was identified by reverse transcriptase PCR followed by nearly complete genome sequencing. Additionally, BoAstV was detected intralesionally in the brain by chromogenic RNA in situ hybridization within neuronal perikarya, axons and dendrites. Phylogenetic analysis of BoAstV-Neuro-Uy revealed a close relationship to neurotropic BoAstVs within the Virginia/Human-Mink-Ovine clade, which contains a growing cadre of neuroinvasive astroviruses. Analyzing the complete coding region of neuroinvasive BoAstVs sequences available in GenBank, we estimated an evolutionary rate of 4.27 × 10-4 (95% HPD 2.19?6.46 × 10-4) nucleotide substitutions/site/year. Phylogeographic analysis suggests that the common viral ancestor circulated in Europe between 1794?1940, and was introduced in Uruguay between 1849?1967, to later spread to North America and Japan. MenosAbstract: Astrovirus species members of the Mamastrovirus genus (family Astroviridae) have been increasingly recognized as neuroinvasive pathogens in various mammals, including humans, mink, cattle, sheep, and pigs. While cases of astrovirus-associated encephalitis have been reported in North America, Europe, and Asia, their presence has never been documented in the Southern hemisphere. This paper describes a case of astrovirus-associated encephalitis in cattle in Uruguay that broadens the geographic distribution and genetic diversity of neuroinvasive astroviruses and provides phylogeographic evidence of viral introduction to the Americas from Europe. A 22-month-old Holstein steer from a farm in Colonia Department, Uruguay developed progressive neurological signs over a 3-days period before dying. Histopathological examination of the brain and proximal cervical spinal cord revealed disseminated, moderate to severe lymphocytic, histiocytic, and plasmacytic poliomeningoencephalomyelitis with neuronal necrosis. A Mamastrovirus strain in the CH13/NeuroS1 clade, that we called bovine astrovirus (BoAstV)-Neuro-Uy, was identified by reverse transcriptase PCR followed by nearly complete genome sequencing. Additionally, BoAstV was detected intralesionally in the brain by chromogenic RNA in situ hybridization within neuronal perikarya, axons and dendrites. Phylogenetic analysis of BoAstV-Neuro-Uy revealed a close relationship to neurotropic BoAstVs within the Virginia/Human-Mink-Ovine... Presentar Todo |
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Palabras claves : |
BOVINE ASTROVIRUS; CATTLE; ENCEPHALITIS; ENFERMEDADES INFECCIOSAS; INFECTIOUS DISEASE; MAMASTROVIRUS; PHYLOGEOGRAPHY; PLATAFORMA SALUD ANIMAL. |
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Thesagro : |
SUD AMERICA; URUGUAY. |
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Asunto categoría : |
E16 Enfermedades de los animales |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/16714/1/fmicb-10-01240.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559012/pdf/fmicb-10-01240.pdf
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Marc : |
LEADER 03592naa a2200349 a 4500
001 1059833
005 2022-09-05
008 2019 bl uuuu u00u1 u #d
024 7 $a10.3389/fmicb.2019.01240$2DOI
100 1 $aGIANNITTI, F.
245 $aThe first case of bovine astrovirus-associated encephalitis in the southern hemisphere (Uruguay), uncovers evidence of viral introduction to the Americas from Europe.$h[electronic resource]
260 $c2019
500 $aArticle history: Received: 22 March 2019//Accepted: 17 May 2019//Published: 04 June 2019. This work was funded by Grants PL-015 N-15156 from INIA and 158 from the ?Programa de Iniciación a la Investigación 2017? from ?Comisión Sectorial de Investigación Científica? (CSIC). MC and RDC acknowledge support from the ?Agencia Nacional de Investigación e Innovación? (ANII) and INIA, respectively, through Ph.D. scholarships. FG acknowledges support from ANII through mobility grant MOV_CA_2018_1_150021.
520 $aAbstract: Astrovirus species members of the Mamastrovirus genus (family Astroviridae) have been increasingly recognized as neuroinvasive pathogens in various mammals, including humans, mink, cattle, sheep, and pigs. While cases of astrovirus-associated encephalitis have been reported in North America, Europe, and Asia, their presence has never been documented in the Southern hemisphere. This paper describes a case of astrovirus-associated encephalitis in cattle in Uruguay that broadens the geographic distribution and genetic diversity of neuroinvasive astroviruses and provides phylogeographic evidence of viral introduction to the Americas from Europe. A 22-month-old Holstein steer from a farm in Colonia Department, Uruguay developed progressive neurological signs over a 3-days period before dying. Histopathological examination of the brain and proximal cervical spinal cord revealed disseminated, moderate to severe lymphocytic, histiocytic, and plasmacytic poliomeningoencephalomyelitis with neuronal necrosis. A Mamastrovirus strain in the CH13/NeuroS1 clade, that we called bovine astrovirus (BoAstV)-Neuro-Uy, was identified by reverse transcriptase PCR followed by nearly complete genome sequencing. Additionally, BoAstV was detected intralesionally in the brain by chromogenic RNA in situ hybridization within neuronal perikarya, axons and dendrites. Phylogenetic analysis of BoAstV-Neuro-Uy revealed a close relationship to neurotropic BoAstVs within the Virginia/Human-Mink-Ovine clade, which contains a growing cadre of neuroinvasive astroviruses. Analyzing the complete coding region of neuroinvasive BoAstVs sequences available in GenBank, we estimated an evolutionary rate of 4.27 × 10-4 (95% HPD 2.19?6.46 × 10-4) nucleotide substitutions/site/year. Phylogeographic analysis suggests that the common viral ancestor circulated in Europe between 1794?1940, and was introduced in Uruguay between 1849?1967, to later spread to North America and Japan.
650 $aSUD AMERICA
650 $aURUGUAY
653 $aBOVINE ASTROVIRUS
653 $aCATTLE
653 $aENCEPHALITIS
653 $aENFERMEDADES INFECCIOSAS
653 $aINFECTIOUS DISEASE
653 $aMAMASTROVIRUS
653 $aPHYLOGEOGRAPHY
653 $aPLATAFORMA SALUD ANIMAL
700 1 $aCAFFARENA, D.
700 1 $aPESAVENTO, P.
700 1 $aUZAL, F.A.
700 1 $aMAYA, L.
700 1 $aFRAGA, M.
700 1 $aCOLINA, R.
700 1 $aCASTELLS, M.
773 $tFrontiers in Microbiology, volumen 10, Article 1240, 04 June 2019. [OPEN ACCESS].Doi: https://doi.org/10.3389/fmicb.2019.01240
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